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Lilly Halts Trials Of PPAR Alpha Agonist After Preclinical Safety Signal

This article was originally published in The Pink Sheet Daily

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Executive Summary

Phase II clinical trials of the atherosclerosis treatment candidate LY674 were halted after a primate study showed fatty liver deposits.

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Development of dual PPAR agonist aleglitazar terminated due to fractures, renal impairment and heart failure reported in the AleCardio study, leaving another hole in Roche’s cardiovascular/metabolic pipeline.

Roche Drops Aleglitazar In Another Cardiology/Metabolics Setback

Development of dual PPAR agonist aleglitazar terminated due to fractures, renal impairment and heart failure reported in the AleCardio study, leaving another hole in Roche’s cardiovascular/metabolic pipeline.

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Merck, AstraZeneca and Roche have already stepped out of the dual PPAR development arena.

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This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

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