Faldaprevir And Simeprevir Outshine Today’s Protease Inhibitors
Phase III data for once-daily protease inhibitors demonstrate advantages over the currently approved candidates in the class, which are given three times daily. But in the rapidly changing and highly competitive hepatitis C market, just where these next-generation drugs might fit in remains unclear.
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For Vertex, the key question is how much is physician and patient concern about the adverse events is already reflected in the softening sales of the hepatitis C drug; for FDA, the question is how effective will label-based risk management be.
Part 2: High costs are built into the rare disease business model. Participants at a roundtable discussion led by Scrip at the J.P. Morgan Healthcare Conference talked about how much they are feeling the pressure on pricing.