Vertex stops VX-745 trials
Executive Summary
Vertex will not proceed with enrollment in the higher-dose cohort in Phase II trials with orally active p38 MAP kinase inhibitor VX-745 following the finding of adverse effects within the central nervous system in one of two animal species receiving high-dose exposure. The company will move ahead on second-generation p38 inhibitors VX-702 and VX-850 for treatment of inflammatory disease, initiating clinical studies with one or both of the candidates in the first half of 2002
Vertex will not proceed with enrollment in the higher-dose cohort in Phase II trials with orally active p38 MAP kinase inhibitor VX-745 following the finding of adverse effects within the central nervous system in one of two animal species receiving high-dose exposure. The company will move ahead on second-generation p38 inhibitors VX-702 and VX-850 for treatment of inflammatory disease, initiating clinical studies with one or both of the candidates in the first half of 2002. |