TLC Evacet Cardiotoxicity Advantage Does Not Outweigh Unclear Efficacy
The Liposome Company's Evacet (liposomal doxorubicin, TLC D-99) has a cardiotoxicity advantage over conventional doxorubicin when used first-line for metastatic breast cancer, the Oncologic Drugs Advisory Committee agreed Sept. 16.
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The impetus for FDA to approve The Liposome Company's Evacet (liposomal doxorubicin, D-99), based on incomplete efficacy data may be lessened by the recent U.S. approval of Pharmacia & Upjohn's Ellence (epirubicin).
Newly released Medicare Part D data sheds light on the sales hit that branded pharmaceutical manufacturers will face when the coverage gap discount program gets under way in 2011