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In Brief: Hybridon GEM91

Executive Summary

Hybridon GEM91: Development of phosphorothioate antisense oligonucleotide is halted after preliminary review of an open-label Phase II trial in nine advanced HIV patients finds that three subjects "experienced decreases in platelet counts that required dose interruption." The data also show "inconsistent responses to the treatment and failed to confirm the decrease in cellular viremia observed in an earlier trial," Cambridge, Mass. company says...
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PS030584

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