Pink Sheet is part of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By


In Brief: Calcium channel blocker study

Executive Summary

Calcium channel blocker study: CCB use in hypertensives "may actually increase the risk of heart attack by 60%" compared to beta blocker or diuretic therapy, according to a University of Washington study released March 10. The retrospective study compares 623 hypertensives who had heart attacks between 1986 and 1993 with a random sample of 2,032 hypertensive patients in the Group Health Cooperative. In the group of patients who were free of clinical cardiovascular disease, "the risk of heart attack was increased by about 60% among those who took either a calcium channel blocker alone or a calcium channel blocker plus a diuretic, compared with those who took a diuretic alone," UW says. In the group administered a CCB or a beta blocker, "calcium channel blockers were again associated with about a 60% increase in the risk of heart attack," UW says. Also, "at the highest prescribed doses, the risk of heart attack among those on calcium channel blockers was almost twice the risk in those on beta blockers." The UW study was funded by the National Institutes of Health...

You may also be interested in...

Part D Discount Liability Coming Into Focus: CMS Releases Drug Cost Data

Newly released Medicare Part D data sheds light on the sales hit that branded pharmaceutical manufacturers will face when the coverage gap discount program gets under way in 2011

FDA Skin Infections Guidance Spurs Debate On Endpoint Relevance

FDA appears headed for a showdown with clinicians and the pharmaceutical industry over the proposed new clinical trial endpoints for acute bacterial skin and skin structure infections, the guidance's approach for justifying a non-inferiority margin and proposed changes in the types of patients that should be enrolled in trials

Shire Hopes To Sow Future Deals With $50M Venture Fund

Specialty drug maker Shire has quietly begun scouting deals with a brand-new $50 million venture fund, the latest of several in-house investment arms to launch with their parent company's pipelines, not profits, as the measure of their worth




Ask The Analyst

Please Note: You can also Click below Link for Ask the Analyst
Ask The Analyst

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts