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Biocine's gp120 HIV vaccine

Executive Summary

Stimulated neutralizing antibodies to HIV-1, which persisted for up to six months, in healthy, uninfected volunteers, according to results of an 18-month Phase I study presented by James Kahn, University of California -- San Francisco, on June 8 at the conference on AIDS. Over a one-year period, 30 volunteers received four injections of either the vaccine combined with adjuvants, an oil and water emulsion called MF-59 or a bacterial fragment called muramyl tripeptide (MTP-PE). Twelve volunteers received either placebo or injections without the HIV vaccine antigen. All volunteers receiving the vaccine produced antibodies against HIV, and neutralizing antibodies were produced against a closely related isolate of the virus, UCSF said. "The vaccine appeared to have better staying power than some other experimental vaccines, as the antibodies persisted in the body for as much as six months after the third injection," a company release states.

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