Pink Sheet is part of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By

UsernamePublicRestriction
UsernamePublicRestriction

ROCHE BACKING HYBRIDON’s ANTISENSE OLIGONUCLEOTIDE R&D

Executive Summary

ROCHE BACKING HYBRIDON's ANTISENSE OLIGONUCLEOTIDE R&D aimed at developing compounds for the treatment of hepatitis B and C viruses and human papilloma virus under a collaboration announced Feb. 4. The three viruses represent new research areas for Hybridon, which has focused mainly on AIDS treatments, the first of which has an IND pending at FDA ("The Pink Sheet" Feb. 1, p. 16). The Worcester, Mass.-based privately held firm also has discovery programs in herpes simplex virus, influenza, cystic fibrosis, Alzheimer's, cancer and organ transplant rejection. Roche will fund research conducted by Hybridon on the three diseases, commit Roche personnel to the project, and make milestone payments according to development benchmarks. In return, Roche will receive an exclusive royalty bearing license to any products that emerge from the collaboration. "Roche has taken an equity position in Hybridon and is committed to a future equity investment," Hybridon said. Although no financial terms of the agreement were released, it is understood to be of similar size to other R&D collaborations involving antisense and related technologies. Antisense-related firms have been avidly courted by major pharmaceutical companies since 1990. Hoechst AG agreed to invest about $30 mil. in Triplex ("The Pink Sheet" Feb. 3, 1992, T&G-4). Ciba-Geigy committed over $30 mil. and bought about $8.5 mil. worth of stock in its funding of Isis ("The Pink Sheet" Nov. 5, 1990, T&G-7). Glaxo backed Gilead with $20 mil. over five years in a July 1990 deal ("The Pink Sheet" July 30, 1990, T&G-6). Genta has signed deals with Procter & Gamble and Wyeth-Ayerst. For Roche, the collaboration gives the company an entry into a new biotechnology field different from those under investigation by its majority-owned biotech affiliate Genentech. Another Roche biotech collaboration outside Genetech is with Protein Design Labs for the SMART Anti-Tac antibody, which has completed a Phase I trial and may be used for treating graft-versus-host disease, kidney transplant rejection and some blood cancers ("The Pink Sheet" Jan. 27, 1992, T&G-8). At the BioEast conference Jan. 25, Hybridon said that it was negotiating two alliances with "large international pharmaceutical houses." The company confirmed Feb. 4 that a second collaborative agreement is still being negotiated.

You may also be interested in...



Part D Discount Liability Coming Into Focus: CMS Releases Drug Cost Data

Newly released Medicare Part D data sheds light on the sales hit that branded pharmaceutical manufacturers will face when the coverage gap discount program gets under way in 2011

FDA Skin Infections Guidance Spurs Debate On Endpoint Relevance

FDA appears headed for a showdown with clinicians and the pharmaceutical industry over the proposed new clinical trial endpoints for acute bacterial skin and skin structure infections, the guidance's approach for justifying a non-inferiority margin and proposed changes in the types of patients that should be enrolled in trials

Shire Hopes To Sow Future Deals With $50M Venture Fund

Specialty drug maker Shire has quietly begun scouting deals with a brand-new $50 million venture fund, the latest of several in-house investment arms to launch with their parent company's pipelines, not profits, as the measure of their worth

UsernamePublicRestriction

Register

LL1134043

Ask The Analyst

Please Note: You can also Click below Link for Ask the Analyst
Ask The Analyst

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts

Cancel