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Warner-Lambert's Cognex

Executive Summary

Shows "statistically significant dose response trends and pairwise comparisons with placebo" in a 12-week placebo-controlled multicenter study of the Alzheimer's drug candidate in 468 patients, company reports at Third International Conference on Alzheimer's Disease and Related Disorders in Padua, Italy July 17. Using doses of Cognex (tacrine) of up to 80 mg/day, "over 50% of treated patients showed improvement on the ADAS Cognitive test." The results also show that "63% of patients were rated as improved by the study clinician and 56% of patients were rated as improved by the caregiver (versus 33% and 28% of patients on placebo, respectively)," Warner-Lambert said. The Cognex expanded access program and a high-dose (120 mg-160 mg) parallel group study are ongoing ("The Pink Sheet" June 22, In Brief).

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