Pink Sheet is part of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By

UsernamePublicRestriction
UsernamePublicRestriction

SANDOZ PUK (PROUROKINASE) CURRENTLY IN PHASE I CLINICALS

Executive Summary

SANDOZ PUK (PROUROKINASE) CURRENTLY IN PHASE I CLINICALS, licensing partner Collaborative Research noted in its just-released annual report for 1986. The Bedford, Mass.-based biotech firm reported that during the year it used a proprietary tissue culture process to produce enough PUK for all remaining trials. PUK, formerly called kidney plasminogen activator, is being developed as an antithrombolytic agent for the treatment of heart attack. "Preliminary results confirm the expectations, based on earlier studies, that the drug appears to be not only effective, but seems to work at relatively lower dosages than does tissue plasminogen activator (TPA)," the report states. Genentech filed an NDA for TPA in 1986. That drug could be approved in 1987. "Although this [thrombolytic] market promises to be highly competitive, Collaborative and its licensee, Sandoz, believe that PUK will gain significant market share," the company stated. "While many potential competitors seeking to produce and market recombinantly made TPA face the possibility of infringing patents that have been filed by others, the current Collaborative/Sandoz natural PUK product is free of this possibility." The company noted it has also teamed up with Triton Biosciences to develop natural interleukin-2 for use in the adoptive immuno-therapy treatment of cancer. "Collaborative Research is pursuing its research and clinical trials with natural IL-2 because it is possible that the natural physiologic form of IL-2 may have certain therapeutic advantages over recombinant forms," the report states. In addition, the report notes that Collaborative is providing a strain of yeast-produced alpha interferon to another biotech firm, Interferon Sciences, which is developing the drug for treatment of gential warts and herpes infections.

You may also be interested in...



Part D Discount Liability Coming Into Focus: CMS Releases Drug Cost Data

Newly released Medicare Part D data sheds light on the sales hit that branded pharmaceutical manufacturers will face when the coverage gap discount program gets under way in 2011

FDA Skin Infections Guidance Spurs Debate On Endpoint Relevance

FDA appears headed for a showdown with clinicians and the pharmaceutical industry over the proposed new clinical trial endpoints for acute bacterial skin and skin structure infections, the guidance's approach for justifying a non-inferiority margin and proposed changes in the types of patients that should be enrolled in trials

Shire Hopes To Sow Future Deals With $50M Venture Fund

Specialty drug maker Shire has quietly begun scouting deals with a brand-new $50 million venture fund, the latest of several in-house investment arms to launch with their parent company's pipelines, not profits, as the measure of their worth

UsernamePublicRestriction

Register

MT142313

Ask The Analyst

Please Note: You can also Click below Link for Ask the Analyst
Ask The Analyst

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts

Cancel