Pink Sheet is part of the Business Intelligence Division of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By

UsernamePublicRestriction
UsernamePublicRestriction

PRAXIS' AIDS COMPOUND COULD BE IN CLINICALS BY END OF 1985

Executive Summary

PRAXIS' AIDS COMPOUND COULD BE IN CLINICALS BY END OF 1985, according to a National Cancer Institute (NCI) spokesman. An IND filing is planned after NIH test-tube study results are published in the New England Journal of Medicine. The unnamed compound is the property of Matrix Research Labs of NYC, a subsidiary of Beverly Hills, Calif.-based Praxis Pharmaceuticals. According to an Aug. 13 press release, preliminary research results obtained by NCI researchers Robert Gallo, MD, and Prem Sarin, MD, suggest that the agent displays antiviral activity against the AIDS-associated HTLV-III virus. Matrix has been supplying the compound to NIH. It has not yet been decided whether clinicals would be conducted by NIH or the company. "The compound utilizes a novel biochemical mechanism that should not result in the toxicity associated with other drugs being investigated for use in the treatment of AIDS," stated Matrix President Arnold Lippa, PhD. NCI has noted that the drug, which is used in Europe to treat children with cystic fibrosis, appears to attack the membrane surrounding the HTLV-III virus, preventing reproduction of the infectious agent without harming immune-triggering T-cells. In addition, the compound is fat soluble, a property which might allow it to cross the blood-brain barrier.
Advertisement
Advertisement
UsernamePublicRestriction

Register

PS008811

Ask The Analyst

Please Note: You can also Click below Link for Ask the Analyst
Ask The Analyst

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts

Cancel