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Korlym’s Mechanism Of Action Complicated Cushing’s Trial Design

This article was originally published in Pharmaceutical Approvals Monthly

Executive Summary

The standard measure of efficacy in Cushing’s syndrome – reduced cortisol levels – is not applicable to mifepristone, which blocks the biological effect of cortisol at the receptor level. Corcept needed to select clinical endpoints from among the multisystem manifestations of Cushing’s syndrome.

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