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Pfizer Touts Bosutinib Advantages, Debuts Hedgehog Inhibitor At ASH

This article was originally published in Pharmaceutical Approvals Monthly

Executive Summary

Among its presentations at the American Society of Hematology meeting, Pfizer debuted Hedgehog Smoothen inhibitor PF-04449913, showing off encouraging Phase I monotherapy data in highly refractory patients. The drug would pair nicely with late-stage bosutinib to hit chronic myelogenous leukemia in two ways: through stem cells and through mature cells, Pfizer’s Rothenberg said.


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