Sanofi's PARP Inhibitor Plus Chemo May Be A Lethal One-Two Punch In Triple-Negative Breast Cancer
This article was originally published in Pharmaceutical Approvals Monthly
Executive Summary
News that Sanofi-Aventis' PARP inhibitor iniparib conferred "significant clinical benefit" in a proof of concept study against metastatic triple-negative breast cancer – published online Jan. 5 by the New England Journal of Medicine – has generated excitement about the approach, but a Phase III study powered for statistically meaningful results in overall and progression-free survival will tell the tale.
You may also be interested in...
Sanofi Oncology’s Transformation Rests On Fedratinib, At Least In The Near-Term
The JAK2 inhibitor for myelofibrosis is the company’s most advanced oncology candidate and will be an anchor for Sanofi as it looks to build a portfolio of next-generation cancer drugs after the late-stage failure of the PARP inhibitor iniparib.
Making Gains Against Triple-Negative Breast Cancer
Researchers reported on new approaches to the knotty problem of triple-negative breast cancer, using genomics to identify ways of targeting the intractable disease with drugs already in the industry pipeline, at the San Antonio Breast Cancer Symposium Dec. 4-8.
Ovarian Cancer: Roche's Avastin And Others Show Potential, But Also Raise The "Value" Question
Roche/Genentech rolled out yet more data on Avastin (bevacizumab) in ovarian cancer at the American Society of Clinical Oncology meeting in Chicago June 3-7, but other companies also had promising results for new therapies that might help break the historical 24-month survival barrier for the difficult cancer.