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The Next Big Thing In Drug Development May Be The Ubiquitin Pathway

This article was originally published in Pharmaceutical Approvals Monthly

Executive Summary

Velcade, Millennium’s successful first-in-class cancer therapy, is held up as a poster drug for manipulating the ubiquitin system to attack disease. Yet it taps only the most rudimentary process of an elegant and little understood cellular mechanism that some are betting will be the next big source of innovation in drug development.

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