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Panitumumab first-line CRC trial

This article was originally published in Pharmaceutical Approvals Monthly

Executive Summary

Amgen/Abgenix initiate a Phase III trial of the epidermal growth factor receptor antagonist panitumumab in first-line metastatic colorectal cancer, the firms announce April 26. The open-label PACCE (Panitumumab Advanced Colorectal Cancer Evaluation) trial will randomize 1,000 patients to receive panitumumab on top of either an oxaliplatin- (Sanofi-Aventis' Eloxatin) or irinotecan-based (Pfizer's Camptosar) regimen. Amgen is also preparing to submit an application in the second half of 2005 for panitumumab's use in third-line CRC (1Pharmaceutical Approvals Monthly April 2005, In Brief)...

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